[2016-Vol.13-Issue 1]Electrospinning and Crosslinking of COL/PVA Nanofiber-microsphere Containing Salicylic Acid for Drug Delivery
Volume 13, Issue 1, January 2016, Pages 143–149
Xiaoli Zhanga, b,Keyong Tanga ,Xuejing Zhenga
a College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China
b Henan Key Laboratory of Functional Textile Materials, College of Textiles, Zhongyuan University of Technology, Zhengzhou 450007, China
Abstract
Porous nanofiber-microsphere mats of collagen (COL)/polyvinyl alcohol (PVA) containing salicylic acid (SA) as model drug were prepared by electrospinning for the assessment of drug delivery system. The electrospun fibrous mats were crosslinked by UV-radiation or glutaraldehyde to weaken the degree of drug burst release and morphology damage when meeting water. The morphology and chemical structures of COL/PVA-SA electrospun fibers were characterized by SEM and FTIR. The crosslinking of UV-radiation did not destroy the morphology of COL/PVA-SA electrospun fibers in the crosslinking process, however, the crosslinking of glutaraldehyde did it. In vitro release studies showed that COL/PVA-SA electrospun fibers efficiently controlled the release of drugs by the crosslinking of UV-radiation for 4 h. The transport mechanism that controlled the release of drugs from electrospun mats was Fickian diffusion.
Keywords
electrospinning;collagen;polyvinyl alcohol;nanofibers;drug delivery
Full text is available at http://www.sciencedirect.com/science/article/pii/S1672652914601682