[2024-Vol.21-Issue 3]Bioinspired 4D Printing Shape-Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment
发布时间: 2024-05-30 10:25  点击:77

Journal of Bionic Engineering (2024) 21:1397–1411  

Bioinspired 4D Printing Shape?Memory Polyurethane Rhinoplasty Prosthesis for Dynamic Aesthetic Adjustment

Jiaqi Liu1,2 · Guiwei Li3 · He Liu2 · Jincheng Wang2 · Hui Wang2 · Xue Gao2 · Qingping Liu3 · Chenyu Wang1 

1 Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun 130021, China

2 Department of Orthopaedics, The Second Hospital of Jilin University, Changchun 130041, China

3 Key Laboratory of Bionic Engineering (Ministry of Education), Jilin University, Changchun 130022, China


The disparity between the postoperative outcomes of rhinoplasty and the expected results frequently necessitates secondary or multiple surgeries as a compensatory measure, greatly diminishing patient satisfaction. However, there is renewed optimism for addressing these challenges through the innovative realm of Four-Dimensional (4D) printing. This groundbreaking technology enables three-dimensional objects with shape-memory properties to undergo predictable transformations under specifc external stimuli. Consequently, implants crafted using 4D printing ofer signifcant potential for dynamic adjustments. Inspired by worms in our research, we harnessed 4D printing to fabricate a Shape-Memory Polyurethane (SMPU) for use as a nasal augmentation prosthesis. The choice of SMPU was guided by its Glass Transition Temperature ( Tg), which falls within the acceptable temperature range for the human body. This attribute allowed for temperature-responsive intraoperative self-deformation and postoperative remodeling. Our chosen animal model for experimentation was rabbits. Taking into account the anatomical structure of the rabbit nose, we designed and produced nasal augmentation prostheses with superior biocompatibility. These prostheses were then surgically implanted in a minimally invasive manner into the rabbit noses. Remarkably, they exhibited successful temperature-controlled in-surgery self-deformation according to the predetermined shape and non-invasive remodeling within a mere 9 days post-surgery. Subsequent histological evaluations confrmed the practical viability of these prostheses in a living organism. Our research fndings posit that worm-inspired 4D-printed SMPU nasal prostheses hold signifcant promise for achieving dynamic aesthetic adjustments.

Keywords 4D printing · Shape memory polyurethane · Rhinoplasty · Self-deformation · Dynamic aesthetic adjustment


Address: C508 Dingxin Building, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China
Copyright © 2024 International Society of Bionic Engineering All Rights Reserved