Journal of Bionic Engineering (2024) 21:1412–1426https://doi.org/10.1007/s42235-024-00495-6

Magnesium-reinforced Electrospun Synthetic-polymer Nanoffbers Designed for Promoting Tissue Growth

Muheeb Raffq1 · Anjum Hamid Rather1 · Rumysa Saleem Khan1 · Taha Umair Wani1,2,3 · Haseeb A. Khan4 · Abdullah S. Alhomida4 · Faheem A. Sheikh1

Abstract

The creation of 3D nanoffbers offering desirable functions for bone regeneration is developed due to the latest improvisations to the electrospinning technique. Synthetic polymers are among the best choices for medical usage due to their lower costs, high tensile properties, and ease of spinnability compared to natural polymers. In this communication, we report a series of interventions to polymers modiffed with Mg-based ffllers for ideal tissue engineering applications. The literature survey indicated that these ffller materials (e.g., nano-sized particles) enhanced biocompatibility, antibacterial activity, tensile strength, and anti-corrosive properties. This review discusses electrospinning parameters, properties, and applications of the poly(ε-caprolactone), poly(lactic acid), poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid), polyurethane, and poly(vinyl pyrrolidone) nanoffbers when modiffed with Mg-based ffllers. This report encourages researchers to use synthetic polymers with Mg as ffllers and validate them for tissue engineering applications.

Keywords Bone regeneration · Magnesium · Nanoffbers · Tissue engineering